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Dr Enas Abu Shah

Dr Enas Abu Shah

  • George and Susan Brownlee Junior Research Fellow in Biomedical Sciences

Profile

I did my undergraduate studies in Biology at the Technion-Israel Institute of Technology, then I moved to a graduate degree in the Multidisciplinary Program in Nanotechnology and Nanoscience with specialty in Biophysics. In 2014 I moved to Oxford to work with Professor Michael Dustin and Professor Omer Dushek as a Postdoctoral Fellow. In 2017 I was awarded a UCB-Oxford Prize to pursue my independent research and I joined Lincoln College as a Susan and George Brownlee Junior Research Fellow in Biomedical Sciences.

College teaching

I give tutorials to Biochemistry students on modern imaging techniques to study biological questions, I also give tutorials on Immunology and critical analysis of research papers.

I run a journal club series for undergraduates in Biochemistry, Biomedical Sciences, and Medicine.

Research

My main research interest is in understanding adaptive immune regulation. Specifically, how a population of white blood cells called regulatory T-cells exerts its suppressive capacity in health and disease. I have been developing a biomimetic 3D platform that involves engineering of resting T-cells (T-regs) from human donors and investigate using imaging techniques to evaluate what paraments affect the activation and regulations of cells. Furthermore, I am looking at phenotyping T-regs from pancreatic cancer patients, which is considered one of the worst modern malignancy. The findings will inspire the design of the model system to represent clinically relevant settings and investigate using a human-derived system potential therapeutics.

Select publications

Abu-Shah E, Demetriou P, Mayya V, Balint S, Kutuzov MA, Dushek O, Dustin ML. A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells. bioRxiv. 2019 Jan 1:587386.

Demetriou P, Abu-Shah E, McCuaig S, Mayya V, Valvo S, Korobchevskaya K, Friedrich M, Mann E, Lee LY, Starkey T, Kutuzov MA. CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation. bioRxiv. 2019 Jan 1:589440.

Han Tan T*, Malik-Garbi M*, Abu-Shah E*, Li J, Sharma A, MacKintosh F, Keren K, Schmidt C, Fakhri N. Self-organised stress patterns drive state transitions in actin cortices. Science Advances, 4.6 (2018): eaar2847 * equal contribution.

Malik-Garbi M, Ierushalmi N, Jansen S, Abu-Shah E, Goode BL, Mogilner A, Keren K. Scaling behaviour in steady-state contracting actomyosin networks. Nature Physics. 2019 Feb 4:1

Abu-Shah E and Keren K. Symmetry breaking in reconstituted actin cortices. eLife, 2014,3:e01433.